广州地区13502例儿童25-羟基维生素D水平及其与季节关系

Study on correlation between 25-hydroxyvitamin D level and seasons among 13502 children in Guangzhou area

目的回顾分析儿童血清25-羟基维生素D[25(OH)D]水平的年龄与季节变化特点,为临床维生素D(VD)制剂的使用提供参考。方法血清25(OH)D采用酶联免疫法检测。分析2009年至2011年2、3、9、10月份广州市妇女儿童医疗中心13 502例0~17周岁体检儿童的血清25(OH)D结果,分为5个年龄组,统计25(OH)D平均水平,计算VD缺乏、不足和过量情况。结果 13 502例儿童血清25(OH)D水平(80.81±42.39)nmol/L,2、3月份组(72.71±33.47)nmol/L,9、10月份组(89.91±49.01)nmol/L,差异有统计学意义,6岁以上组有性别差异,25(OH)D水平随年龄增加而降低,两个季节5个年龄组血清25(OH)D水平比较及VD不足和缺乏例数比较差异均有统计学意义。VD缺乏者482例(3.57%)、1 850例(13.7%)分别以25(OH)D<37.5 nmol/L和<50.0 nmol/L(1)为参照;各年龄组VD缺乏(1)分别为春季8.19%、13.97%、37.72%、52.63%、57.92%;夏季2.38%、4.15%、10.36%、16.85%、27.47%;VD不足者6 973例(51.64%);过量和中毒分别为34例(0.25%)、35例(0.26%)。结论广州地区儿童VD水平较低,尤其在春季,学龄儿童VD缺乏较严重,有必要依年龄、季节适时补充VD,鼓励儿童增加户外活动的时间。

Objective The age and seasonal variation in children＇s serum 25- hydroxyvitamin D （25 （OH） D ] were analyzed retrospective and to provide some guides on clinical application. Methods The serum 25 （OH） D level was detected by using enzyme-linked immunosorbent assay kit in 13 502 children that took health ex- amination in Guangzhou Women and Children＇s Medical Center in February, march, September and October from 2009 to 2011. The cases were divided into five age groups. The average levels, deficiency and overdose of vitamin D （VD） , were analyzed. Results The average 25 （OH）D in serum was （80.81＋42.39） nmol/L in 13 502 cases, （72.71 ＋ 33.47） nmol/L in Feb. and Mar. group, （ 89.91 ＋ 49.01 ） nmol/L in Sep. and Oct. group. There was statis- tically significant difference on serum 25 （OH）D level between seasons and between boys and girls for 6 years older groups. The serum 25 （ OH ） D levels significantly decreased with increasing age. There were statistically significant differences in serum 25 （OH） D levels and between the VD deficiency and the lack of number of cases in the 5 age groups of the two seasons. The number of VD deficiency was 482 cases （3.57%） whose 25 （OH） D 〈 37.5 mnol/L, and 1850 cases （13.7%） whose 25 （OH） D 〈 50.0 nmol/L. The VD deficiency in each age group was 8.19%, 13.97%, 37.72%, 52.63%, 57.92% in Spring, and 2.38%, 4.15%, 10.36%, 16.85%, 27.47% in Summer. The number of lack of VD was in 6 973 cases （51.64%） ; Excessive and poisoning of VD were 34 cases （0.25%） and 35 cases （0.26%）. Conclusions Children had a relatively low level of VD in Guangzhou area, especially in the spring and school-age children with more severe VD deficiency. It is necessary to supplyVD timely in accordance with the age and season, and children were encouraged to spend more time outdoors.