超声联合病理指标预测乳腺癌腋窝淋巴结转移的价值

The value of ultrasound combined with pathological factors for predicting axillary lymph node metastasis in breast cancer patients

目的:探究超声联合病理指标在预测乳腺癌腋窝淋巴结(ALN)转移中的价值。方法:选择2016年3月至2017年4月在广西医科大学第一附属医院进行手术,术中进行腋窝淋巴结分期的乳腺癌患者314例。对纳入患者的病理指标及超声特征进行单因素分析筛选腋窝淋巴结转移的危险因素,并对筛选出的危险因素按照病理组、超声组及联合组进行多因素Logistic回归分析。绘制各组受试者工作特征曲线(ROC),计算ROC曲线下面积(AUC)。结果:314例乳腺癌患者中,166例(52.87%)存在ALN转移,148例(47.13%)无ALN转移。病理组、超声组及联合组的AUC分别为0.737(95%CI:0.684~0.784)、0.783(95%CI:0.733~0.827)、0.833(95%CI:0.788~0.873)。联合组的AUC大于病理组和超声组(P<0.05)。结论:超声联合病理指标能够提高乳腺癌患者ALN转移预测的准确性。

Objective： To investigate the value of ultrasound combined with pathological factors in predicting ax- illary lymph node （ALN） metastasis in breast cancer patients. Methods： 314 breast cancer patients treated in our hospital from March 2016 to April 2017 were enrolled. The risks for ALN metastasis were analyzed by univariate analysis and multivariate logistic regression analysis. Receiver operating characteristic （ROC） curve was made to evaluate the value of ultrasound, pathological factors and this combination for ALN metastasis （P〈0.05）. Results： Of 314 breast cancer patients, 166 cases （52. 87% ） had ALN metastasis. The area under the ROC curve （AUC） of ultrasound, pathological factors and the combination were 0. 737 （95% CI： 0. 684-0. 784）, 0. 783 （95% CI： O. 733-0. 827） and 0. 833 （95% CI： 0. 788-0. 873）. Ultrasound combined with pathological factors had highest AUC （P〈0. 05）. Conclusions： Ultrasound in combination with pathological factors could elevate the accuracy for predicting ALN metastasis in breast cancer patients.