摘要
目的:探讨肌萎缩侧索硬化症发病的相关危险因素。方法:选择2011年1月至2016年11月在广西医科大学第一附属医院确诊的肌萎缩侧索硬化症患者15例,进行1∶4病例对照研究,通过比较患者与对照的一般情况、既往病史、遗传家族史、生活习惯、饮食习惯、生活环境、职业暴露因素等多个方面的情况,采用单因素和多因素条件Logistics回归分析分析肌萎缩侧索硬化症的相关危险因素。结果:单因素分析结果显示,两组是否常喝牛奶、是否常吃腌制食品、是否常吃动物内脏以及头颈部外伤史比较,差异均有统计学意义(P<0.05),OR值分别为6.19(95%CI:1.11~34.39,P=0.04)、4.78(95%CI:3.13~209.78,P=0.01)、9.22(95%CI:1.12~20.45,P=0.04)、25.64(95%CI:3.13~209.78,P=0.002)。多因素Logistic回归分析显示头颈部外伤史是肌萎缩侧索硬化症的危险因素,OR值为12.50(95%CI 1.21~129.40,P=0.03)。结论:头颈部外伤史是肌萎缩侧索硬化症发病的独立危险因素。
Objective: To investigate the related factors associated with amyotrophic lateral sclerosis (ALS). Methods: A 1:4 case-control study was conducted in Guangxi province, 15 cases ALS patients were selected from January 2011 to November 2016, and controls were matched with same sex and similar age. Both cases and controls were investigated with questionnaires. The data were analyzed by conditional Logistic model. Results: It was found that the head trauma history was the risk factors for ALS after comparing the general condition, previous medical history, living habits, dietary habits, living environment, occupational exposure factors, etc. between cases and controls. Conclusion: The head trauma history was the risk factor for ALS.
出处
《广西医科大学学报》
CAS
2018年第1期112-115,共4页
Journal of Guangxi Medical University
基金
广西医科大学2016-2017学年"未来学术之星"大学生课外创新科研项目(No.WLXSZX17071)
关键词
肌萎缩侧索硬化症
病例对照
危险因素
amyotrophic lateral sclerosis
case-control study
etiological factors