茵陈颗粒 苯巴比妥 维生素B_2联合早期应用对新生儿病理性黄疸的辅助治疗效果观察

Early application of oriental wormwood particle, Phenobarbital, vitamin B_2 in adjuvant treatment of neonatal pathological jaundice

目的观察茵陈颗粒、苯巴比妥、维生素B_2联合早期应用对新生儿病理性黄疸的辅助治疗效果。方法将2014年1月—2017年4月在我院治疗的80例新生儿病理性黄疸患儿作为研究对象,应用随机数字表法分为对照组、观察组各40例。对照组实施保暖、补液、双面蓝光照射等治疗,观察组在此基础上加以茵陈颗粒、苯巴比妥、维生素B_2治疗。观察2组临床疗效、治疗前后胆红素水平与不良反应等。结果 2组基本治愈率、治疗第4天后胆红素下降水平、黄疸消失时间等对比,观察组优于对照组,差异有统计学意义(P<0.05);2组不良反应发生率对比,差异无统计学意义(P>0.05)。结论茵陈颗粒、苯巴比妥、维生素B_2联合早期应用对新生儿病理性黄疸的辅助治疗效果良好,可显著缩短褪黄时间、降低胆红素水平,安全高效。

Objective To observe the effects of early application of oriental wormwood particle, phenobarbital, vitamin B2 in adjuvant treatment of neonatal pathological jaundice.Methods 80 cases of neonatal pathological jaundice treated in our hospital from January 2014 to April 2017 were selected, and they were divided into control group and observation group by random number table, 40 eases in each group. Control group was given keeping warm, fluid infusion and two-sided blue light irradiation, while observation group added oriental wormwood particle, phenobarbital and vitamin B2. The clinical efficacy, bilirubin levels before and after treatment, adverse reactions in two groups were observed. Results The basic cure rate, decreased bilirubin level after treatment for 4d, disappearance time of jaundice in observation group were better than those in control group （P〈0.05）; There was no statistical difference in the incidence of adverse reactions between the two groups （P〉0.05）. Conclusion Early application of oriental wormwood particle, phenobarbital, vitamin B2 in adjuvant treatment of neonatal pathological jaundice is effective, it can shorten time of clearing jaundice and decrease bilirubin level, which is safe and efficient.