白藜芦醇纳米醇质体体外抗氧化作用的研究

Antioxidant Activity of Resveratrol Nanoethosomes in vitro

目的:为提高白藜芦醇的溶解性和稳定性,制备醇质体包裹白藜芦醇,研究其抗氧化作用。方法:采用乙醇注入法制备白藜芦醇纳米醇质体,分别用DPPH自由基清除能力、ABTS自由基清除能力以及铁离子还原法(FRAP)来评价其体外抗氧化作用。结果:白藜芦醇纳米醇质体对DPPH、ABTS自由基清除率以及Fe SO4当量均高于白藜芦醇原料药。结论:纳米醇质体能增强白藜芦醇体外抗氧化能力。

Aim： In order to improve the solubility and stability of resveratrol, naneethosome was prepared to encapsulate resveratrol to study its anti-oxidation effect. Methods： Nanoethosomes loaded resveratrol were prepared by ethanol injection method. The anti-oxidative effects of resveratrol nanoethosomes in vitro were evaluated by DPPH free radical scavenging assay, ABTS free radical scavenging assay and ferrous reduction method （FRAP） respectively. Results： The results demonstrated that resveratrol nanoethosomes had higher clearance rate than free resveratrol on DPPH and ABTS. The FeSO4 equivalent of resveratrol nanoethosomes were also higher than free resveratrol. Conclusion： These results indicate that nanoethosomes can enhance the antioxidant capacity of resveratrol in vitro.