去铁酮联合去铁胺治疗小儿重型β地中海贫血铁过载的疗效分析

Analysis on the Curative Effect of Defriprone Combined with Deferoxamine in the Treatment of Iron Overload for Children with Severe β-Mediterranean Anemia

目的研究去铁酮(DFP)联合去铁胺(DFO)治疗小儿重型β地中海贫血铁过载的临床效果。方法选取我院2012年2月至2015年8月期间收治的56例重型β地中海贫血铁过载患儿,随机平均分为两组。DFO组单纯采用DFO治疗,联合组采用DFO联合DFP治疗。比较两组患儿的治疗效果、血清铁蛋白(SF)水平和不良反应。结果联合组的总反应率为89.29%,明显高于DFO组的64.29%(P<0.05)。治疗后,两组患儿的SF水平较治疗前均有所降低。治疗前、治疗3个月、治疗6个月及治疗9个月,两组患儿的SF水平比较差异均无统计学意义(P>0.05);治疗12个月,联合组的SF水平明显低于DFO组(P<0.05)。两组患儿的不良反应发生率比较差异无统计学意义(P>0.05)。结论 DFP联合DFO治疗重型β地中海贫血铁过载患儿,效果显著,临床总反应率高,SF水平明显改善,不良反应少,值得临床推广应用。

Objective To study the clinical effect of defriprone （DFP） combined with deferoxamine （DFO） in the treatment of iron overload for children with severe/J-mediterranean anemia. Methods 56 cases of children with iron overload of β-mediterranean anemia admitted to our hospital from February 2012 to August 2015 were selected and randomly divided into two groups equally. The DFO group was only treated with DFO, while the combined group received DFO combined with DFP. The treatment effects, serum ferritin （SF） levels and adverse reactions were compared between two groups. Results The total response rate of combined group was 89.29%, significantly higher than 64.29% of DFO group （P 〈0.05）. After treatment, the SF levels of two groups decreased compared with those before treatment. No statistical difference was found in the SF levels between two groups before treatment and 3 months, 6 months and 9 months after treatment. The SF level of combined group was significantly lower than that of DFO group 12 months after treatment （P〈0.05）. No statistical difference was found in the incidence of adverse reactions between two groups （P 〉0.05）. Conclusions DFP combined with DFO in the treatment of iron overload for children with severe β-mediterranean anemia has significant effect, high clinical total response rate, and significant improvement of SF level with fewer adverse reactions, which is worthy of clinical promotion and application.