美洛培南联合萘夫西林在化脓性脑膜炎患儿中的临床效果

Analysis of the Clinical Effect of Meropenem Combined with Nafcillin in Children with Purulent Meningitis

目的:探讨临床有效治疗化脓性脑膜炎患儿的方法,为化脓性脑膜炎患儿临床治疗和研究提供依据。方法:本文选取的96例化脓性脑膜炎患儿均为笔者所在医院2014年1月-2015年12月收治的患者,随机将患者分成治疗组和对照组,每组48例。对照组选择头孢曲松和阿莫西林舒巴坦治疗,治疗组选择美洛培南和萘夫西林治疗。对患者临床症状改善时间等指标和临床综合治疗效果进行观察和比较。结果:(1)治疗组患者的体温下降时间、颅高压消失时间和CSF恢复正常时间优于对照组,差异有统计学意义(P<0.05);(2)治疗组患者的总有效率组高于对照组,差异有统计学意义(χ~2=12.080,P=0.000)。结论:在临床治疗脓性脑膜炎患儿的实践过程中,采用美洛培南联合萘夫西林治疗的临床效果显著,是临床治疗脓性脑膜炎患儿的理想选择。

Objective： To investigate the clinical effective treatment method of children with purulent meningitis, so as to provide the basis for the clinical treatment and research for children with purulent meningitis.Method： From January 2014 to December 2015, 96 eases of purulent meningitis in children admitted to our hospital were chosen.They were randomly divided into the treatment group and the control group, and 48 cases in each group.The control group was taken with Ceftriaxone and A moxieillin Sulbactam for treatment, and the observation group was taken with Meropenem and Nafcillin for treatment.The clinical symptoms of improvement time and other indicators and clinical comprehensive treatment effect were ohserved and compared.Result： （1）The time of temperalure dropping, intracranial hypertension disappearance time, CSF resume normal time in the treatment group were significantly better than the control group, and the differences between the two groups were significant（P〈0.05）.（2）The total efficiency rate in the treatment group was significantly higher than the control group, and the difference was significant（χ^2=12.080, P=0.000）.Conelusion： In clinical practice of children with purulent meningitis, the clinical effect of Meropenem combined with Nafcillin therapy is remarkable, and it is the ideal choice for the clinical treatment of purulent meningitis in children.