半乳凝集素-3对心力衰竭患者的诊断及评估作用

Diagnosis and evaluation of Galectin - 3 in patients with heart failure

目的探讨半乳凝集素-3（Galectin-3，Ga-3）对心力衰竭（心衰）患者的诊断及评估作用。方法选取40例心力衰竭患者，测定治疗前后Ga-3、脑钠肽（BNP），行Ga-3与BNP的相关性分析，行Ga-3与心功能分级的相关性分析。治疗1周后检查心脏彩超，测定射血分数（EF）、左室舒张末期内径（LVEDD），行Ga-3、BNP与EF、LVEDD的相关性分析，按治疗效果分为有效组及无效组，比较两组治疗前后Ga-3、BNP水平。按心功能分级分组，比较各组Ga-3、BNP水平。随访3个月，记录再住院及死亡事件。结果①Ga-3与BNP、LVEDD、心功能分级呈正相关，Ga-3、BNP与EF呈负相关。②治疗有效组治疗后BNP较治疗前明显下降（P〈0．05），而Ga-3未见明显下降（P〉0．05）。治疗无效组治疗后Ga-3、BNP较治疗前明显升高（P〈0．05）。③随访3个月，发生心脏不良事件组Ga-3、BNP水平较不发生心脏不良事件组明显升高。结论Ga-3与心衰患者心肌重构有关，可评估心衰患者预后，可作为诊断治疗、危险分层及评估预后的生物标志物。

Objective To investigate the diagnosis and evaluation of Galectin -3 in patients with heart failure. Methods Forty patients with heart failure were included in this study. Before and after treatment, Galectin -3, BNP were measured. The relationship between Ga -3 and BNP was analyzed. One week after treatment, echocardiography was performed and EF, LVEDD were measured. The relationship between Ga - 3, BNP and EF, LVEDD was analyzed. The treatment effect was divided into effective group and ineffective group. The levels of Ga - 3, BNP of the two groups were compared. Grouping according to cardiac function, correlation between Ga - 3 and cardiac function classification was analyzed. The patients were followed up for 3 months to record the information about rehospitalization and death. Results ①Correlation analysis showed that the serum levels of Ga -3 and BNP, LVEDD, cardiac functional grading had a positive correlation; Correlation analysis showed that the serum levels of Ga-3, BNP and EF had a negative correlation. ②The effective rate of BNP in treatment group was significantly lower than that before treatment （ P 〈 0.05 ） ; No significant decrease was seen in Ga - 3 （ P 〉 0.05）. After treatment, the Ga -3 and BNP of the treated group were significantly higher than those before treatment （P 〈 0.05）. ③The patients were followed up for 3 months, the level of Ga - 3, BNP in the adverse event group was significantly higher than that in the group without adverse cardiac events. Conclusion In patients with heart failure, correlation analysis shows that the serum levels of Ga - 3 and cardiac hypofunction, myocardial remodeling have a negative correlation. It can assess the prognosis in patients with heart failure. It can be used as a new biomarker for diagnosis, treatment, risk stratification and evaluation of prognosis in patients with heart failure.