多溴联苯醚对学习记忆影响的研究进展

Advances in the impact of polybrominated diphenyl ethers on learning and memory

多溴联苯醚(polybrominated diphenyl ethers,PBDEs)作为一种性能优良的阻燃剂,在世界范围内尤其是在作为制造业大国的中国得到了广泛的应用。PBDEs是一种持久性有机污染物(persistent organic pollutants,POPs),具有生物富集性和不易降解的特性,研究证实PBDEs可以危害生殖系统、内分泌系统、免疫系统等,环境中低浓度PBDEs暴露会影响神经发育及学习记忆。本文就近年来国内外有关PBDEs的污染状况、对学习记忆的影响、这种影响的可能机制等方面的研究进行了综述。

As excellent flame retardants, polybrominated diphenyl ethers （ PBDEs } are widely applied all around the world, es- pecially in China, which is a big manufacturing country. PBDEs are also a kind of persistent organic pollutants （POPs） , which are bio-aceumulative and non-degradable. Studies have confirmed that PBDEs do harm to reproductive system, endocrine system and immune system. PBDEs of low concentration in the environment affect neural development, learning and memory. This paper re- views domestic and overseas studies on the pollution status of PBDEs, their effects on learning and memory, and the possible un- derlying mechanisms in recent years.