头颈鳞状细胞癌人乳头状瘤病毒检测进展

Progress in the detection of human papillomavirus in squamous cell carcinoma of the head and neck

不同部位的头颈鳞状细胞癌（squamous cell carcinoma of the head and neck,SCCHN）病因学并不完全相同，但由于均起源于消化道、呼吸道的鳞状上皮黏膜，仍然有一些共同的风险因素。目前公认的SCCHN的风险因素是吸烟和饮酒。除此之外，人乳头状瘤病毒（humanpa pillomavirus，HPV）的某些高风险亚型，已证实在SCCHN的发生、发展过程中起始动和促进作用。而且HPV阳性的SCCHN患者，对于放化疗的反应效果更好，预后也好于HPV阴性的患者。HPV感染与SCCHN的发病密切相关，不同的检测方法、肿瘤不同的解剖位置起源、研究人群的地缘差异、样本来源年代的不同导致了SCCHN患者HPV感染率的差别很大。因此，如何有效、快速、经济、简单地检测SCCHN组织样本的HPV感染状态，越来越受到人们的重视。

Squamous cell carcinomas of the head and neck （SCCHN）, which comprise a heterogeneous group of malignancies derived from the squamous epithelial mucosa of the upper aero- digestive tract, share some simlar but not all the same risk factors. Heavy consumption of alcohol and/or tabacco use is the main risk factor. However, infection with oncogenic human papillomavirus （HPV） has been demonstrated to play an important role in the carcinogenesis in a subset of SCCHN, especially in oropharyngeal carcinoma. And HPV~ SCCHN has a better response to chemotherapy/ radiotherapy and a better prognosis. The HPV prevelance differs in literatures, due to different detection methods, anatomic sites of tumors, geographical locations and time of study populations. Therefore there is an increasing demand for effective, rapid, economic and simple methods to evaluate the status of HPV infection in tumor tissues of SCCHN.