桥本氏甲状腺炎合并甲状腺癌的免疫相关研究

Immunological correlation of Hashimoto＇s thyroiditis coexistent with thyroid carcinoma

桥本氏甲状腺炎（Hashimoto’s thyroiditis，HT）合并甲状腺癌（thyroid carcinoma，TC）近年来发病率呈现明显的上升趋势，二者间的关系—直存在着争议；临床特征上的紧密关系提示他们之间可能存在复杂的免疫学关联，HT可能导致甲状腺癌的发生或HT本身作为甲状腺癌抗肿瘤免疫应答出现。本文就桥本氏甲状腺炎合并甲状腺癌的免疫相关研究做一综述。

The incidence rate of Hashimoto＇s thyroiditis （HT） coexistent with thyroid carcinoma （TC） has an upward tendency in recent years. The association of this two disorders has long been a topic of controversy. Because an clinical correlation between HT and TC exists, immunological links between these two conditions are possible and probably rather complex. Hashimoto＇s thyroiditis may lead to thyroid carcinoma, or appear as an antitumor immune response. In this article we review the researches describing these potential immunological mechanisms that might lead to the synchronous appearance of HT and TC.