青蒿素衍生物的合成及抗肿瘤活性研究进展

Progress in Synthesis and Anticancer Activities of Artemisinin Derivatives

青蒿素是从菊科植物黄花蒿中分离提取得到的一种含有过氧桥片段的倍半萜内酯,具有广泛的抗疟活性,对多种疟疾均有很好的疗效。近年来的研究表明,青蒿素还有一些其他重要的药理活性,如抗肿瘤、抗菌和杀虫等。其中,青蒿素衍生物的抗肿瘤活性也是国内外研究的热点之一。因此,本文综述了近年来青蒿素衍生物的合成及抗肿瘤活性研究进展。

Artemisinin is a terpene lactone containing a 1, 2, 4-tiroxane ring system extracted from the Chinese herb huanghuahao, which is a excellent antimalarial drug. Recently, studies show that artemisinin also has some other important pharmacological activities, such as antitumor, antibacterial and insecticidal properties, etc. Among them, antitumor activity of artemisinin derivatives is one of the hot spot of research at home and abroad. Therefore, this paper will summarize the progress in synthesis and anticancer activities of artemisinin derivatives.