脂蛋白（a）与自发性蛛网膜下腔出血发病的关系研究

Association of lipoprotein （a） level with spontaneous subarachnoid hemorrhage

目的探讨脂蛋白（a）[Lp（a）]与自发性蛛网膜下腔出血（SSAH）发病的关系。方法选择云南省第一人民医院神经外科自2014年11月至2015年12月收治的SSAH患者34例为患者组，同期体检的健康体检者40例为对照组，分别于住院次日清晨和体检当日清晨空腹状态下采集静脉血2mL，送检验科进行总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白AI（ApoAI）、载脂蛋白B（ApoB）、Lp（a）水平的检测。采用Pearson相关性检验分析患者组Lp（a）水平与其他血脂指标的相关性。结果患者组血浆Lp（a）水平[（170．50±144．58）mg／L]明显高于对照组[（84．28±57．96）mg／L]，差异有统计学意义（P〈0．05）；2组受试者血浆TC、TG、HDL—C、LDL—C、ApoAI、ApoB水平比较差异均无统计学意义（P〉0．05）。Pearson相关性分析显示患者组血浆Lp（a）水平与TC、TG、HDL—C、LDL．C、ApoAI、ApoB水平均无明显相关关系（P〉0．05）。结论血浆Lp（a）是SSAH发病的危险因子。

Objective To investigate the relationship between lipoprotein[a] （Lp[a]） level and risk of onset of spontaneous subarachnoid hemorrhage （SSAH）. Methods Thirty-four patients with SSAH, admitted to our hospital from November 2014 to December 2015, were chosen as patient group, and another 40 healthy volunteers were collected as control group. Morning fasting venous blood was collected, and levels of plasma Lp （a）, total cholesterol （TC）, glycerol triester （TG）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, apolipoprotein AI （ApoAI） and apolipoprotein B （ApoB） were detected. Pearson correlation analysis was used to analyze the correlations of Lp （a） with various lipid components. Results As compared with control group （84.28±57.96 mg/L）, patient group had significantly higher Lp（a） level （[170.50±144.58] mg/L, P〈0.05）; TC, HDL-C, LDL-C, ApoAI and ApoB levels showed no significant differences between the two groups （P〉0.05）. Pearson correlation analysis indicated that Lp（a） level did not correlate to TC, HDL-C, LDL-C, ApoAI and ApoB levels （P〉0.05）. Conclusion Plasma Lp （a） level is a risk factor for the onset of SSAH.