琥珀酸亚铁缓释片配合生血宁片对妊娠期缺铁性贫血的疗效探讨

Efficacy of Ferrous succinate zyban Combined with Shengxuening Tablets on Treatment of Iron Deficiency Anemia in Pregnancy Period Deficiency Anemia in Pregnancy Period

目的:探讨琥珀酸亚铁缓释片配合生血宁片对妊娠期缺铁性贫血的疗效及安全性。方法:收集妊娠期缺铁性贫血孕妇80例,随机分为对照组40例和治疗组40例。对照组口服力蜚能胶囊,1次/d,2粒/次。治疗组口服琥珀酸亚铁缓释片,1~2片/次,1次/d;生血宁片,轻度贫血者,2片/次,2次/d;中、重度贫血者,2片/次,3次/d。比较两组血液学水平和铁代谢变化及临床疗效。比较两组不良反应发生率。结果:治疗后,治疗组的红细胞计数(RBC)、血红蛋白(Hb)、平均红细胞体积(MCV)、平均红细胞血红蛋白浓度(MCHC)、血清铁(SI)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)水平显著高于对照组(P<0.01)。治疗组的总有效率为97.5%,显著优于对照组的81.08%(P<0.05)。治疗组的不良反应发生率为10%,对照组为5.41%,两组差异无统计学意义(P>0.05)。结论:琥珀酸亚铁缓释片配合生血宁片对妊娠期缺铁性贫血的疗效显著,且安全性好。

Objective：To investigate efficacy of Ferrous succinate zyban combined with Shengxuening tablets on treatment of iron deficiency anemia in pregnancy period and safety.Methods：80 cases with iron deficiency anemia in pregnancy period were randomly divided into control group （40 cases） and treatment group （40 cases）.Cases of control group were orally treated with niferex capsule （ltime/d and 2granules/time）.Treatment group was treated with Ferrous suceinate zyban （1-2 tablets/time and qd） combined with Shengxuening tablets 2 times/d and 2 tablets/time for mild anemia, 2 times/d and 2 tablets/time for moderate and severe anemia.Course were treated for 4 weeks in two groups.Hematology level,iron metabolism, efficacy were compared between two groups.Occurrence rate of untoward effect was recorded in two groups.Results ： After treatment, RBC, Hb, MCV, MCHC, SI, SF, and TSAT of of treatment group were evidently higher than those of control group （P〈0.01）.Total efficacy rate of treatment group was 97.5% ,which was obviously higher than control group 81.08% （P〈0.05）. There was no statistical significance in occurrence rate of untoward effect between treatment group （10%） and control group （5.41%）（P〉0.05）.Conelusion：Effieaey of Ferrous suecinate zyban combined with Shengxuening tablets on treatment of iron deficiency anemia in pregnancy period is significantly and good security.