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二甲双胍增强子宫内膜癌化疗药物敏感性的临床研究 被引量:1

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摘要 目的:探讨二甲双胍(Met)增强子宫内膜癌化疗药物敏感性的临床价值。方法:选取2014年1月~2017年1月在我院就诊的子宫内膜癌患者50例,随机抽签分为顺铂(DDP)单药组和DPP+Met联合用药组各25例,体外培养子宫内膜癌Ishikawa细胞,使用MTT检测细胞增殖活性,流式细胞术检测两药单用及合用对癌细胞凋亡和周期的影响。结果:Met浓度和时间呈依赖性逐渐增强现象,与单药组相比,Met+DDP联合组的细胞凋亡率更高(P<0.05)。结论:相比单纯的顺铂化疗,采用二甲双胍联合顺铂进行化疗,可有效抑制癌细胞的繁殖和增长,增强DDP化疗药物的敏感性,可直接作用于IGF-1和m TOR等细胞因子,达到抑制癌细胞扩散的效果,值得在临床上推广。
出处 《北方药学》 2018年第2期125-126,共2页 Journal of North Pharmacy
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