摘要
目的探讨长链非编码RNA HOTAIR在胰腺癌患者中的表达水平。方法选取2010年10月—2016年12月山西医科大学第一医院普外科诊断明确的胰腺癌标本共54例。对照组为良性胰腺手术者(如胰腺外伤、胰腺囊肿内引流术)。通过q RT-PCR方法检测HOTAIR m RNA的表达水平,统计分析胰腺癌组织与正常对照组间的差异。结果与对照组相比,胰腺癌患者HOTAIR m RNA表达水平升高(P<0.05),胰腺癌TNM分期I、Ⅱ与Ⅲ、Ⅳ期组间比较无明显差异。结论长链非编码RNA HOTAIR与胰腺癌的发生发展有关。
Objective To investigate the expression level of long chain non-coding RNA HOTAIR in patients with pancreatic cancer. Methods From October 2010 to December 2016, 54 cases of pancreatic cancer were diagnosed in the department of general surgery in the frst hospital of Shanxi Medical University. The control group was a benign pancreas operation （such as pancreatic trauma and pancreatic cyst drainage）. The expression level of HOTAIR mRNA was detected by qRT-PCR method. The diference between the pancreatic cancer tissue and the normal control group was statistically analyzed. Results Compared with the control group, the expression of HOTAIR mRNA in the patients with pancreatic cancer was increased （P 〈 0.05）. There was no signifcant diference in TNM staging betweenⅠ, Ⅱand stage Ⅲ and Ⅳ groups in pancreatic cancer. Conclusion Long non coding RNA HOTAIR is associated with the development of pancreatic cancer.
出处
《中国继续医学教育》
2017年第33期119-120,共2页
China Continuing Medical Education
