脂肪来源间充质干细胞与免疫调节因子间作用的研究进展

Research progress on the relationship between ADSCs and immunomodulatory factors

间充质干细胞(MSCs)是中胚层中具有高度自我更新和多向分化潜能的非造血多能干细胞,可以分化为成脂细胞、成骨细胞、成软骨细胞、肝细胞、心肌细胞、神经元干细胞、胰岛样细胞等。MSCs具有免疫调节特性,可通过分泌吲哚胺-2,3-双加氧酶(IDO)和前列腺素E2(PGE2)来发挥免疫调节作用,同时又能在炎性因子如干扰素γ(IFN-γ)的预刺激下增强其免疫调节功能。研究发现,在脂肪组织中存在丰富的,使MSCs成为成年干细胞非常有吸引力的来源。本文对目前脂肪来源间充质干细胞(ADSCs)和以上3种免疫调节因子之间相互作用的研究进展作一综述。

Mesenchymal stem cells(MSCs) are defined as undifferentiated cells that are capable of self renewal andfunctionally capable of differentiating into adipocytes, osteoblasts, chondrocytes, hepatocyte-like cells, myogenic-like cells,neuron-like cells, and islet-like cells. MSCs possess immunomodulatory properties according to secrete indoleamine-2,3-dioxygenase(IDO) and prostaglandin E2(PGE2) to play the role of immunomodulatory. Moreover, pre-stimulation ofinterferon-γ(IFN-γ) can promote the immunomodulatory function of MSCs. High abundance of MSCs found in adiposetissue makes it a very attractive source of adult stem cells. This article reviews the recent progress in the interaction betweenadipose derived mesenchymal stem cells(ADSCs) and three immunomodulatory factors.