摘要
目的分析两种不同的HBeAg检测方法对于乙型肝炎患者使用替比夫定抗病毒治疗的价值分析。方法择取2015年7月—2016年7月收治的慢性乙型肝炎患者150例为研究对象,使用替比夫定抗病毒治疗,依照就诊顺序,将其分为观察组、对照组2组,每组75例。检测HBV DNA及HBeAg水平,分析价值。结果观察组HBV DNA转阴率为84%(63/75),HBeAg和HBV DNA水平下降;无效12例,HBeAg和HBV DNA水平下降,但无转阴。对照组HBV DNA转阴率为80%(60/75),无效15例,HBeAg和HBV DNA水平下降,但无转阴。和治疗前相比,治疗后3~12月两组的HBV DNA、HBeAg均明显降低,且呈现随治疗时间延长,下降幅度更大的趋势。结论开展两种不同的HBeAg定量检查,均能够真实地反映HBV DNA复制详情。两种不同的HBeAg检测方法均可用于评估乙型肝炎患者使用替比夫定抗病毒治疗价值。
Objective To analyze the value of 2 different HBeAg detection methods in hepatitis B patients who were treating with telbivudine. Methods 150 cases of chronic hepatitis B in patients between July 2015 to July 2016, who were treating with telbivudine were chosen as the study subjects,in accordance with the order of treatment, they were divided into two groups,the control group and the observation group（n =75）, HBV DNA and HBeAg levels were detected , their values were analyzed .Results The negative conversion rate of HBV DNA in the observation group was 84% （63/75）, and the level of HBV DNA and HBeAg decreased; 12 cases were invalid, and no negative conversion happened, however the HBeAg and HBVDNA level declined. On contrast, the negative conversion rate of HBV DNA in the control group was 80% （60/75）, and 15 cases were invalid, that was no negative conversion happed, however the HBeAg and HBVDNA level declined.The patients’HBeAg and HBV DNA level in both the observation group and the control group were significantly lower after treating of 3 to 12 months, compared with before start to treating. And it also showed that the decline trend of patients’ HBV DNA and HBeAg level went down significantly as the treating time went longer. Conclusion Both of the two types of the HBeAg quantitative examination can tellthe HBV DNA replication details, and both of them can be used to evaluate the value of antiviral therapy of telbivudine to patients of hepatitis B
出处
《中国卫生标准管理》
2017年第28期134-137,共4页
China Health Standard Management
