利奈唑胺治疗40例重症结核性脑膜炎效果观察

Effect of Linezolid on 40 Cases With Severe Tuberculous Meningitis

目的研究利奈唑胺应用于晚期重症结核性脑膜炎患者治疗中的疗效。方法抽取本院在2015年1月—2017年1月收治的40例结核性脑膜脑炎患者作为研究样本,先进行抗痨治疗,对于脑压持续升高、蛋白高1.5 g以上、颅内多发性肉芽肿病变增多、病变范围广泛的结核性脑膜炎或结核性脊髓炎造成患者截瘫的患者加用利奈唑胺针剂或片剂,统计40例结核性脑膜炎患者的临床治疗效果。结果 40例患者中,脑压高18例,蛋白高8例,颅内病变增多13例。治愈4例,好转34例。结论在抗痨治疗的基础上早期加用利奈唑胺治疗重症结核性脑膜炎可获得良好效果。

Objective To study the curative effect of linezolid on the treatment of patients with advanced severe tuberculous meningitis. Methods 40 patients with tuberculous meningoencephalitis in our hospital from January 2015 to January 2017 were selected as the research sample, the 40 patients with tuberculous meningitis were treated anti tuberculosistreatment frst. For paraplegic patients caused by tuberculous meningitis or tuberculous myelitis with brain pressure continued to rise, the protein higher than 1.5 g and increased intracranial multiple granulomatous lesions and lesions in a wide range, linezolid injection or tablet was added. The clinical treatment effect of the 40 cases was recorded. Results Among the 40 cases, 18 cases with high intracranial pressure, 8 cases with higher protein and 13 cases with increased intracranial lesions. 4 cases were cured and 34 cases were recovered. Conclusion On the basis of anti-tuberculosis treatment, early linezolid treatment for severe tuberculous meningitis achieves good results.