两种药物联合治疗多重耐药鲍曼不动杆菌肺炎疗效观察

Observation Curative Effect on Combination of Two Drugs in the Treatment of Multidrug-Resistant Acinetobacter Bauman Pneumonia

目的探讨替加环素与头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺炎疗效。方法选择2016年2月—2017年3月80例多重耐药鲍曼不动杆菌肺炎患者分组。对照组采用头孢哌酮舒巴坦治疗,联合用药组则联合替加环素与头孢哌酮舒巴坦治疗。比较两组多重耐药鲍曼不动杆菌肺炎疗效;细菌清除率;干预前后患者白细胞计数、C反应蛋白、降钙素原。结果联合用药组多重耐药鲍曼不动杆菌肺炎疗效高于对照组,P<0.05;联合用药组细菌清除率高于对照组,P<0.05;干预前两组白细胞计数、C反应蛋白、降钙素原相近,P>0.05;干预后联合用药组白细胞计数、C反应蛋白、降钙素原优于对照组,P<0.05。结论替加环素与头孢哌酮舒巴坦治疗多重耐药鲍曼不动杆菌肺炎疗效肯定,可更好清除细菌,降低炎症水平。

Objective To investigate the efficacy of tegacycline and cefoperazone sulbactam in the treatment of multiple drug resistant Acinetobacter Bauman pneumonia. Methods 80 cases of multidrug-resistant acinetobacter bauman pneumonia from February 2016 to March 2017 were selected. The control group was treated with cefoperazone and sulbactam, and the combined treatment group combined with tegoperazine and cefoperazone sulbactam. The efficacy of two groups of multidrug-resistant acinetobacter bauman pneumonia, bacterial clearance rate, leukocyte count, C reactive protein and calcitonin were compared beforeand after intervention. Results The curative efect of multi drug resistant Acinetobacter Bauman pneumonia in the combined drug group was higher than that of the control group, P 〈 0.05; The rate of bacterial clearance in the combination group was higher than that in the control group, P 〈 0.05. The two groups of white blood cell count, C reactive protein and calcitonin were similar before intervention, P 〉 0.05. The leukocyte count, C reactive protein and calcitonin in the combined treatment group were better than those in the control group, P 〈 0.05. Conclusion Tegoperazine and cefoperazone sulbactam are efective in the treatment of multiple resistant Acinetobacter Bauman pneumonia, which can better remove bacteria and reduce the level of infammation.