利培酮和奥氮平治疗难治性精神分裂症78例疗效对比

Comparison of effects of Risperidone and Olanzapine in treatment of refractory schizophrenia

目的:观察利培酮和奥氮平治疗难治性精神分裂症的疗效。方法:选取78例难治性精神分裂症患者为本次研究对象,按照区组随机化法将所有患者均分为研究组与对照组,对照组39例患者给予奥氮平治疗,研究组39例患者给予利培酮治疗,比较两组患者临床治疗效果。结果:随着临床治疗时间的推移,两组患者病情均好转,其中研究组患者同一时间段精神分裂症症状量表(PANSS)得分明显低于对照组(P<0.05),研究组患者不良反应发生率明显低于对照组(7.7%VS17.9%)(P<0.05)。结论:对于难治性精神分裂症患者给予利培酮可有效改善个体患者临床症状,不良反应发生率低。

Objective To observe therapeutic effects of Risperidone and Olanzapine in treatment of refractory schizophreniapatients. Methods： 78 patients with refractor^^ schizophrenia were randomly selected and divided into experimental group and control group according to the block randomization method. 39 patients in the control group were given Olanzapine treatment, while the experi-mental group of 39 patients was given Risperidone treatment. The clinical effects of the two groups were compared. Results ： With the clinical treatment, the two groups had a certain degree of improvement in the condition. The positive and negative symptom scale （PANSS） score of the experimental group was significantly lower than that of the control group, and the adverse reaction incidence rate （7.7% ） was also significantly lower than that of the control group （17. 9 % ） （ P 〈0. 05）. Conclusions ： Risperidonecan be used to improve the clinical symptoms of the patients with refractory schizophrenia with a lower adverse reaction incidence rate.【