氨溴索不同给药方式治疗急性呼吸窘迫综合征的临床观察

Clinical observation of different delivery ways of ambroxol in the treatment of acute respiratory distress syndrome

目的观察氨溴索不同给药方式治疗急性呼吸窘迫综合征的临床效果。方法选取我院收治的呼吸窘迫综合征患者70例为研究对象,根据不同治疗方法分为静脉组和序贯组,各35例。静脉组用静脉滴注法治疗,序贯组用序贯给药法治疗。比较两组患者治疗前、后动脉PaO_2,SaO_2,PaO_2/FiO_2等血气指标情况,血清中TNF-α、IL-6、IL-10水平及治疗总有效率。结果治疗后,两组患者的PaO_2、SaO_2、PaO_2/FiO_2、IL-10水平均升高,TNF-α、IL-6均显著降低,且序贯组明显优于静脉组(P<0.05);序贯组患者治疗总有效率高于静脉组(P<0.05)。结论盐酸氨溴索治疗呼吸窘迫综合征患者时,序贯给药方式较静脉给药方式效果更佳。

Objective To observe the clinical effects of different delivery ways of ambroxol in the treatment of acuterespiratory distress syndrome. Methods Seventy cases of patients with acute respiratory distress syndrome in our hospitalwere enrolled and divided into venous group （which was treated with intravenous drip, n=35） and sequential group （whichwas treated with sequential administration, n=35） according to different treatment methods. The arterial PaO2, SaO2, PaO2/FiO2 and other blood gas indexes before and after treatment, the levels of TNF-α, IL-6 and IL-10 in serum and the totaleffective rate of treatment were compared between the two groups. Results After treatment, the levels of PaO2, SaO2, PaO2/FiO2 and IL-10 in the two groups significantly increased, and the levels of TNF-α and IL-6 significantly decreased in thetwo groups （P〈0.05）, the levels of those indexes in the sequential group were better than the venous group （P〈0.05）. Thetotal effective rate of the sequential group was higher than that of the venous group （P〈0.05）. Conclusion The sequentialadministration of ambroxol hydrochloride in the treatment of patients with respiratory distress syndrome is better than theintravenous administration.