新生儿呼吸暂停应用纳洛酮联合氨茶碱的疗效分析

Curative effect of naloxone combined with aminophylline on neonatal apnea

目的观察纳洛酮联合氨茶碱治疗新生儿呼吸暂停的临床疗效。方法选取2015年4月至2017年4月在我院出生并确诊为新生儿呼吸暂停综合征患者70例为研究对象,随机分为观察组和对照组,各35例。对照组患儿给予纳洛酮治疗,观察组患儿在对照组基础上给予氨茶碱治疗,1个疗程后比较两组患儿呼吸暂停发生次数、持续时间及血氧饱和度、心率、临床总有效率。结果治疗后观察组患儿呼吸暂停发生次数较对照组更少,持续时间较对照组明显更短,血氧饱和度、心率均升高,差异有统计学意义(P<0.05);治疗后观察组患儿治疗总有效率为88.57%,高于对照组的77.14%(P<0.05)。结论纳洛酮联合氨茶碱对新生儿呼吸暂停具有显著疗效。

Objective To observe the curative effect of naloxone combined with aminophylline on neonatal apnea.Methods Sixty-eight cases of neonatal apnea treated in our hospital from April 2014 to April 2017 were enrolled as thestudy objects, and were randomly divided into observation group and control group, with 35 cases in each group. Thecontrol group was given naloxone, while the observation group was given aminophylline on the basis of the control group.Aftera course of treatment, the number and duration of apnea, oxygen saturation, heart rate, and total effective rates werecompared between the two groups. Results After treatment, the apnea frequency were less and the apnea duration in theobservation group were less lower than those in the control group （P〈0.05）, and the blood oxygen saturation, heart rate inthe observation group were higher than those in the control group （P〈0.05）; the total effective rate of the observation groupwas 88.57% , which was higher than 77.14% of the control group （P 〈0.05）. Conclusion Naloxone combined withaminophylline has a significant effect in the treatment of neonatal apnea.