人乳头瘤病毒、趋化因子受体7与宫颈癌及癌前病变的相关性分析

Correlation analysis of the human papillomavirus, chemokine receptor 7and cervical cancer and cervical precancerous lesions

目的观察人乳头瘤病毒(HPV)、趋化因子受体7(CXCR7)与宫颈癌及宫颈癌前病变的相关性。方法选取我院2012年8月至2015年8月收治的50例宫颈癌患者作为宫颈癌组,80例确诊为宫颈上皮内瘤样病变(CIN)患者作为CIN组,30例正常子宫颈者作为对照组。比较三组研究对象的CXCR7阳性表达水平,比较HPV-16、HPV-18在宫颈癌、CIN及正常宫颈中的相对表达量。结果宫颈癌组患者的CXCR7阳性表达率明显高于CIN组和对照组患者,CIN组患者的CXCR7阳性表达率明显高于对照组(P<0.05)。宫颈癌组及CIN组患者HPV-16、HPV-18表达量显著高于对照组(P<0.05)。宫颈癌组患者HPV-16、HPV-18表达量显著高于CINⅠ、CINⅡ、CINⅢ级患者的表达量(P<0.05)。CIN组随着等级升高,HPV-16、HPV-18表达量逐渐升高(P<0.05)。结论 HPV-16、HPV-18、CXCR7与宫颈癌及宫颈癌前病变存在一定相关性。

Objective To observe the correlation between human papilloma virus （HPV）, chemokine receptor 7 （CXCR7）and cervical cancer and cervical precancerous lesions. Methods From August 2012 to August 2015, 50 patients withcervical cancer were selected as the cervical cancer group, 80 patients with cervical intraepithelial neoplasia （CIN） wereenrolled as the CIN group, and 30 patients with normal cervix were collected as the control group. The CXCR7 postiveexpression levels were compared among the three groups, and the relative expressions of HPV-16 and HPV-18 werecompared among cervical cancer, precancerous lesions and normal cervix. Results The positive expression rate of thecervical cancer group was higher than those in the CIN group and control group, and that of the CIN group was higher than thecontrol group（P〈0.05）. The HPV-16 and HPV-18 expressions in the cervical cancer group and CIN group were higher thanthat of the control group （P〈0.05）. The HPV-16 and HPV-18 expressions in the cervical cancer group were higher thanthose of patients with CIN Ⅰ, CIN Ⅱ and CINⅢ （P〈0.05）. In CIN group, the expression of HPV-16 and HPV-18 increasedwith the increasing of grade （P〈0.05）. Conclusion There is a certain correlation between HPV-16, HPV-18, CXCR7 and cervical cancer and cervical precancerous lesions.