幽门螺杆菌感染与胃蛋白酶原、胃泌素-17相关性研究

Correlation study between Helicobacter pylori infection and serum pepsinogen and gastrin-17

目的研究胃癌高发区陕北安塞县幽门螺杆菌(Hp)感染与血清胃蛋白酶原I(PGI)、胃蛋白酶原II(PGII)、PGI/PGII(PGR)以及胃泌素-17(G-17)浓度的相关性。方法收集148例健康查体居民,同时进行13C呼气试验检测及血清PGI、PGII、G-17浓度的检测;根据检测结果,将研究对象分为Hp阳性组和阴性组,分析比较两组血清PGI、PGII、G-17浓度及PGR值变化。结果 Hp总感染率为40.54%,其中男性感染率为43.08%,女性感染率为38.55%;不同性别Hp感染率比较,差异不显著(P>0.05)。Hp阳性组的血清PGI、PGII、G-17浓度均高于阴性组,PGR低于阴性组,差异均具有统计学意义(P<0.05)。PGⅡ高值组Hp感染率高于正常值组(P<0.05)。PGR低值组Hp感染率高于高值组(P<0.05)。G-17高值组Hp感染率高于正常值组(P<0.05)。结论 HP感染继发血清中PGI、PGII及G-17浓度升高,可作为辅助诊断HP感染及HP感染相关性胃病。

Objective To study the correlation between Helicobacter pylori（Hp） infection and the levels of serum pepsinogen I（PGI）, serum pepsinogen II（PGII）, PGI/PGII（PGR） and gastrin-17（G-17） in Ansai County of North of Shaanxi Province which has high incidence of gastric cancer. Methods A total of 148 cases of healthy residents were selected, performing 13 C-breath test and serum pepsinogen（PGⅠPGII） and gastrin-17（G-17） levels were detected simultaneously. According to the test results, the subjects were divided into Hp positive group and negative group. The concentration of pepsinogen（PGⅠ PGⅡ） and gastrin-17 as well as PGR（PGⅠ/PGⅡ） were analyzed and compared. Results The total infection rate of Hp was 40.54%, of which the male infection rate was 43.08% and the female infection rate was38.55%, there was no significant difference in the gender（P〉0.05）. The serum concentrations of PGI, PGII and G-17 in the Hp positive group were higher than those in the negative group and PGR was lower than that in the negative group（P〈0.05）. The infection rate of Hp in the high PGⅡ value group was higher than that in the normal value group（P〈0.05）. Hp infection rate in the low PGR value group was higher than that in the high value group（P〈0.05）. Hp infection rate in the G-17 high value group was higher than the normal value group（P〈0.05）. Conclusion PGⅠ, PGII and G-17 concentration increased secondary to Helicobacter pylori infection, which can be used as an auxiliary diagnosis of Hp infection and HP infection-related disease.