C反应蛋白和降钙素原在新生儿ABO溶血病中的临床意义

Clinical significance of C-reactive protein and procalcitonin in ABO hemolytic disease of newborns

目的探讨新生儿ABO溶血病合并感染患儿的C反应蛋白(CRP)、降钙素原(PCT)变化特点。方法择取我院收治的ABO溶血患儿100例,按照患儿是否存在感染情况,划分为感染组(n=53)和非感染组(n=47)。回顾分析两组患儿的临床资料,分析比较两组的诊断结果。结果非感染组患儿入院第1、3天的PCT、CRP水平均明显低于感染组患儿(P<0.05)。非感染组患儿PCT、CRP异常值检出率均明显低于感染组患儿(P<0.05)。感染诊断过程中,PCT准确度、特异度以及灵敏度均明显优于CRP(P<0.05)。结论 ABO溶血病合并感染患儿的CRP、PCT水平相对较高,PCT诊断相对于CRP具有更高的准确性、特异度、灵敏度。

Objective To investigate the changes of C-reactive protein（CRP） and procalcitonin（PCT） in newborns with ABO hemolytic disease complicated infection. Methods A total of 100 children with ABO hemolysis admitted in our hospital were divided into infection group（n=53） and non-infection group（n=47） according to the presence or absence of infection. The clinical data of the two groups were retrospectively analyzed, and the diagnostic results of the two groups were analyzed and compared. Results The levels of PCT and CRP on the first day and the third day after admission in the noninfected group were significantly lower than those in the infection group（P〈0.05）. The detection rates of abnormal values of PCT and CRP in the non-infected group were significantly lower than those in the infection group（P〈0.05）. During the diagnosis of infection, the accuracy, specificity and sensitivity of PCT were significantly better than those of CRP（P〈0.05）.Conclusion The levels of CRP, PCT in children with ABO hemolytic disease associated with infection are relatively high.Compared with CRP, the diagnostic performance of PCT has high accuracy, specificity and sensitivity.