替米沙坦联合复方丹参滴丸对原发性老年2级高血压患者血压及血管内皮功能的影响

Effects of telmisartan combined with Danshen dripping pills on blood pressure vascular endothelial function in patients of primary grade 2 hypertension

目的观察替米沙坦联合复方丹参滴丸对原发性老年2级高血压(中危组)患者血压及血管内皮功能的影响。方法选取就诊于潍坊市人民医院高血压专家门诊以及保健三科病房的原发性老年2级高血压(中危组)患者82例,年龄65~75岁。分为复方丹参滴丸组(观察组)41例和替米沙坦组(对照组)41例,两组患者均在常规服用阿司匹林、他汀的基础上,晨起口服40 mg替米沙坦,观察组加服复方丹参滴丸每次10丸,每天3次。疗程均为4周。比较各组治疗前后患者的血压、血清一氧化氮(NO)、内皮素(ET-1)、基质金属蛋白酶9(MMP-9)、踝肱指数(ABI)的变化。结果与治疗前相比,治疗后两组收缩压、舒张压均降低,组间比较差异有统计学意义。与治疗前相比,观察组血清NO升高,ET-1降低、MMP-9降低,ABI升高。与对照组治疗后比较,观察组经治疗后血清NO升高,ET-1下降,ABI降低。结论替米沙坦联合复方丹参滴丸在降压的基础上,能够进一步改善血管内皮功能。

Objective Observation of Telmisartan combined with compound Danshen dripping pills on effect of vascular endothelial function in patients of primary grade 2 hypertension(Moderate Risk Group). Methods The patients( n = 82) with senile primary grade 2 hypertension(high risk group)were chosen from Weifang People's Hospital hypertension clinic and the third Department of health care ward there were 48 males and 34 females with age of 65-75 years old and randomly divided into the treatment group(group1, n = 41) and the control group(group 2, n = 41). 2 groups of patients were given telmisartan(40 mg) daily in the morning, and the treatment group were additionally with Compound Danshen Dripping Pills(10 pills at a time) for 3 times daily,all for 12 weeks. The changes of blood pressure, serum NO, endothelin 1(ET-1) and matrix metalloproteinase(MMP-9) in patients were compared between the two groups before and after treatment. Results Compared with the two groups before treatment,systolic BP and diastolic BP increased,ET-1 and MMP-9 decreased in group 2 compared with those before treatment. Compared with group 1,NO increased,ET-I and MMP-9 decreased in group 2 after treatment. Conclusion Telmisartan combined with compound Danshen dripping pills can improve the function of vascular endothelium on the basis of reducing blood press.