中性粒细胞CD64指数在婴幼儿社区获得性肺炎诊断中的应用价值

Value of n CD64 for diagnosis of community-acquired pneumonia in infants and young children

目的探讨中性粒细胞CD64(nCD64)指数测定结果在婴幼儿社区获得性肺炎诊断和疗效评价中的价值。方法对婴幼儿细菌感染组60例、支原体感染组60例以及健康组60例采用流式细胞仪测定nCD64指数,同时测定C反应蛋白(CRP)、降钙素原(PCT),并动态监测随着抗感染治疗的应用,以及细菌感染组第3天的nCD64指数、PCT、CRP表达水平。结果细菌感染组nCD64指数、PCT、CRP与健康组和支原体感染组比较,差异均有统计学意义(均P<0.05),与治疗后组比较差异均有统计学意义(均P<0.05)。nCD64指数诊断细菌性肺炎的灵敏度最高为81.6%。结论 nCD64指数测定有助于婴幼儿社区获得性肺炎的早期诊断、鉴别诊断以及对抗感染疗效的考核。

Objective To assess the value of neutrophils nCD64 index for diagnosis of community-acquired pneumonia in infants and young children. Methods Infants and young children with community-acquired pneumonia were enrolled in the study, including 60 cases of bacterial infections, 60 cases of mycoplasma infection; and 60 healthy young children and infants served as control group. The nCD64 index was measured by flow cytometry, the CRP and PCT were determined. There indexes were determined in bacterial infection group at 3 days after treatment. Results There were significant differences inCD64 index, CRP and PCT levels between bacterial pneumonia group and healthy controls, between bacterial pneumonia group and mycoplasma pneumonia group(P<0.05). For bacterial pneumonia group, there were significant differences inCD64 index, CRP and PCT levels(P<0.05) before and after treatment. nCD64 index was positively correlated with CRP. The sensitivities and specificities of nCD64 for diagnosis of bacterial pneumonia were 81.6%, respectively. Conclusion Determination of nCD64 index is of value in diagnosis of bacterial lung infection and evaluation of therapeutic effectiveness in infants and young children.