低氧预处理与高氧预处理在脊髓损伤后神经保护作用的相关研究进展

Research Related to Neural Protection of Hypoxic and Hyperoxic Preconditioning after Spinal Cord Injury(review)

重复急性间歇性低氧能够增加运动神经元中生长因子与营养因子的表达,在突触可塑性和神经保护中改变关键分子的表达。低氧预处理能有效提高干细胞移植后的存活率,并对神经功能具有保护作用。间歇性低氧也是急性脊髓损伤后增强呼吸运动的方法之一。高压氧预处理能增强中枢神经对缺氧及缺血的耐受性,有效保护细胞、组织结构,缩短神经细胞的再生周期,促进神经纤维再生。有必要进一步探讨低氧及高氧预处理在脊髓损伤中的作用机制。

Repeated acute intermittent hypoxia promotes the expression of growth factors and neurotrophic factors, as well as the key molecules for neural protection and plasticity. Hypoxic preconditioning may improve the survival rate of transplanted stem cells and protect the neural function. Meanwhile, acute intermittent hypoxia can be an approach to improve respiratory function after spinal cord injury. Hyperbaric oxygen may improve the neural tolerance to hypoxia and ischemia, to protect the structure of cells and tissues, and promote the neuranagenesis. It is important to study the role of hypoxic and hyperoxic preconditioning in spinal cord injury.