丁苯酞对脑小血管病患者认知功能及脑血管储备功能的影响

Effect of butylphthalide on the cognitive function and cerebrovascular reserve capability in patients with cerebral small vascular disease

目的探讨丁苯酞对脑小血管病(SVD)患者认知功能及脑血管储备(CVR)功能的影响。方法选择SVD患者80例,随机分为对照组和治疗组各40例。对照组给予常规基础治疗,治疗组在对照组治疗基础上加服丁苯酞软胶囊。治疗前后应用经颅多普勒(TCD)屏气试验检测屏气指数(BHI),评价CVR功能,同时进行神经电生理检测P300及蒙特利尔认知评估量表(MoCA)评定患者认知功能,并观察治疗过程中的不良反应。结果 (1)与治疗前比较,对照组治疗后3月MoCA评分有显著变化(P<0.05),P300及BHI在两个治疗时间点均无显著变化(P>0.05);治疗组治疗后1月及3月MoCA评分、P300及BHI均有显著变化(P<0.05);(2)与对照组同时间点比较,治疗组治疗后1月及3月MoCA评分、P300及BHI差异有统计学意义(P<0.05);(3)2组患者治疗过程中无特殊不良反应。结论丁苯酞能够改善SVD患者认知功能及CVR功能,是一种安全有效的治疗方法。

Objective To investigate the impact of butylphthalide on the cognitive function and cerebrovascular reserve ca pability in patients with cerebral small vascular disease （SVD）. Methods Eighty patients diagnosed with SVD were selected and randomly divided into control group and treatment group, 40 patients in each group. Patients in both groups were treated by the traditional basic therapy, but those in the treatment group were given butylphthalide soft capsules orally. The CVR function was e- valuated by BHI in breathing-holding test of the transcranial Doppler ultrasound （TCD） before and after treatment. At the same time,the P300 and the Montreal cognitive assessment scale （MoCA） were performed to assess the cognitive function of patients. Meanwhile,related indicators such as coagulation functions were monitored,and adverse reactions were observed. Results Corn pared with prior-treatment, the MoCA score in the control group was significantly different after three months treatment （P〈0.05）, but the P300 and BHI were unchanged at both treatment time points （P 〉0.05）. The MoCA scores, P300 and BHI were significantly different at both treatment time points in the treatment group （P〈0.05）. compared with the control group, the Mo CA scores,P300 and BHI were significantly different at both treatment time points in the treatment group （P〈0.05）. There were no specific adverse reactions during the treatment of the two groups. Conclusion Butylphthalide can improve the cognitive function and CVR function of SVD patients,and it is a safe and effective treatment.