广西北部湾地区成人化脓性脑膜炎脑脊液培养的病原菌分析

Pathogenanalysis of adult purulent meningitis in Beibu Gulf of Guangxi

目的探讨广西北部湾地区成人化脓性脑膜炎脑脊液培养的病原菌分布及其对抗菌药物的敏感性。方法回顾分析2015-01-2017-06钦州市第一人民医院收治的51例化脓性脑膜炎患者的脑脊液涂片及培养结果,并分析病原菌的药物敏感性。结果 51株病原菌,以真菌感染的新型隐球菌为主,共28株,革兰阴性杆菌6株,脑膜炎奈瑟菌1株。革兰阳性球菌12株,革兰阳性球菌中以链球菌为主。在培养出的真菌中,均对氟康唑、伏立康唑、伊曲康唑、两性霉素B、氟胞嘧啶敏感。结论广西北部湾地区成人化脓性脑膜炎病原菌以新型隐球菌为主。

Objective To investigate the distribution of pathogens in cerebrospinal fluid culture of adult purulent menmgms in Beibu Gulf of Guangxi and its sensitivity to antimicrobial agents. Methods The results of cerebrospinal fluid smear and culture in 51 patients with purulent meningitis in our hospital from January 2015 to June 2017 were retrospectively analyzed, and the drug sensitivity of pathogens was analyzed. Results Among the 51 strains of pathogenic bacteria,there were mainly 28 strains of Cryp- tococcus neoformans with fungal infection, 6 strains of Gram-negative bacilli, 1 Strain of Neisseria gonorrhoeae. 12 strains of Gram- positive cocci were mainly streptococcus. In cultured fungi, fluconazole, Aripiprazole, itraconazole, anphotericin B, and fluorouracil were all sensitive. Conclusion The pathogen of adult purulent meningitis in Beibu Gulf area of Guangxi is mainly Cryptococcus neoformans.