急性主动脉夹层发病机制研究进展

Pathogenesy and research progress of acute aortic dissection

急性主动脉综合征（AAS）属于心血管疾病中的急危重症，严重威胁人类健康及生命。主动脉夹层（AAD）作为AAS的重要分型，高发于中老年人群，凶险程度远胜于脑梗、心梗以及恶性肿瘤。随着现代医学和生物信息技术的不断发展，人们对于AAD发病机制的认识不断更新。本文将综述近年来关于AAD的相关研究，从病因、病生理变化、病理机制、分子机制、遗传易感性及单核苷酸多态性等角进行归纳探讨，为进一步深入研究AAD提供一定的理论支持，为AAD的预防、诊断及治疗提供一定的理论依据。

Acute aortic syndrome （AAS） is a critical cause of cardiovascular disease, which seriously threatens human health and life. AAD, as an important classification of AAS, is of high incidence in the elderly population, which is far worse than the cerebral infarction, myocardial infarction and malignant tumors. With the continuous development of modern medicine and bioinformatics, people＇s awareness of the pathogenesis of AAD is constantly updated. In this paper, we will summarize the recent studies on aortic dissection （AAD） from the etiology, disease physiological changes, pathological mechanisms, molecular mechanisms, genetic susceptibility and single nucleotide polymorphisms. This review provides some theoretical support further for AAD study, prevention, diagnosis and treatment.