MMPs／TIMPs在近视发生发展中的机制研究进展

Research Progress on MMPs/TIMPs and the Mechanism of Myopia Formation and Development

近年来近视的发病率逐年增高。多项针对近视动物模型的实验及人体临床研究均表明基质金属蛋白酶（MMPs）及其抑制剂基质金属蛋白酶抑制剂（TIMPs）在近视发生发展中发挥着重要作用。笔者从基因表达、mRNA水平、蛋白质浓度等多个方面探讨了MMPs／TIMPs对巩膜及眼内其他组织的影响，并对其与近视发生机制的关系作一总结。

The incidence of myopia has increased in recent years. Studies of myopic animal models and clinical trials have demonstrated that matrix metalloproteinases （MMPs） and tissue inhibitors of matrix metalloproteinases （TIMPs） play important roles in the development of myopia. We summarizes the association between MMPs/TIMPs and myopia development. It also clarifies the effect of MMPs/TIMPs on scleral and other ocular tissues from the perspective of gene expression, mRNA levels, and protein concentrations.