特发性肺纤维化急性加重研究进展

Developments in researches on acute exacerbation of idiopathic pulmonary fibrosis

特发性肺纤维化急性加重(acute exacerbation of idiopathic pulmonary fibrosis,AE-IPF)是指特发性肺纤维化患者出现新的弥漫性肺泡异常改变导致急性、显著的呼吸道症状。过去通常认为AE-IPF是特发的,无有效方法预防急性加重事件发生及显著改善预后;而最新研究表明AE-IPF可以继发于已知原因(包括肺部感染、误吸等)。该文根据AE-IPF的最新研究就AE-IPF的病因或危险因素、治疗及预防措施进行了综述。

Acute exacerbation of idiopathic pulmonary fibrosis （AE-IPF） is defined as an acute and clinically significant respiratory deterioration characterized by evidence of new, widespread alveolar abnormality. In the past, AE-IPF was considered to be idiopathic, which was hard to be prevented and its prognosis was hard to be obviously improved; the latest researches have shown that AE-IPF can be triggered by known causes, including pulmonary infection, aspiration, etc. This review summarizes the etiology or risk factors, treatment and prevention of AE-IPF according to the latest researches.