他莫昔芬联合小剂量睾酮治疗特发性少弱精子症的随机对照研究

A randomized controlled trial of tamoxifen combined with low dose testosterone in the treatment of idiopathic oligoasthenospermia

目的评估他莫昔芬联合小剂量睾酮对特发性少弱精子症的治疗效果,并与单纯应用他莫昔芬的治疗效果进行比较。方法采用前瞻性随机对照研究,对2016年6月至2017年3月到邢台不孕不育专科医院就诊的特发性少弱精子症患者77例,采用分层随机分组的方法分为研究组和对照组,对用药前和用药3个月后精液分析中的精子浓度、前向运动精子百分率进行观察分析。结果研究组治疗前后精子浓度、前向运动精子百分率比较,差异均有统计学意义(P<0.05);对照组治疗前后精子浓度差异有统计学意义(P<0.05);两组治疗后,精子浓度比较差异有统计学意义(P<0.05)。结论他莫昔芬联合小剂量睾酮治疗特发性少弱精子症,有助于改善精子浓度,效果优于单一使用他莫昔芬。

Objective To evaluate the efficacy of tamoxifen combined with low - dose testosterone in the treatment of idiopathic oligoasthenospermia,and to compare the efficacy with tamoxifen alone. Methods A prospective randomized controlled trial was conducted on 77 patients with idiopathic oligoasthenospermia who were treated in Xingtai Infertility Specialist Hospital from June 2006 to March 2017. They were randomly divided into two groups： the study group and the control group. The sperm concentration and the percentage of forward spermatozoa in semen analysis were observed and analyzed before and 3 months after treatment. Results There were significant differences in sperm concentration and forward motile sperm before and after treatment in the study group（P 〈0. 05 ） ; The differences of sperm concentration before and after treatment in the control group was statistically significant （ P 〈 0.05 ） ; There were significant differences in sperm concentration between the study group and the control group（P 〈 0. 05）. Conclusion Tamoxifen combined with low - dose testosterone in the treatment of oligoasthenospermia can improve sperm concentration and is superior to tamoxifen alone.