银杏达莫联合醒脑静治疗脑出血患者疗效及对外周血S100B、神经肽Y水平的影响

Curative Effects of Yinxing amo and Xingnaojing on Patients with Cerebral Hemorrhage and Effects on Peripheral Blood S100 Band Neuropeptide Y

目的:探讨银杏达莫联合醒脑静治疗脑出血患者疗效及对外周血S100B、神经肽Y(NPY)水平的影响。方法:选取2015年1月至2017年6月武汉市普仁医院收治的脑出血患者80例随机分为观察组及对照组。对照组采用醒脑静治疗,观察组采用银杏达莫联合醒脑静治疗。记录比较2组脑水肿吸收疗效,治疗前后NIHSS评分、S100B和NPY变化,并评价2组用药安全性。结果:治疗14 d后,观察组脑血肿吸收的总有效率为90%,显著高于对照组的72.5%(P<0.01);2组NIHSS评分均显著低于其治疗前(P<0.01),观察组较对照组降低更显著(P<0.01)。与其治疗前比较,2组治疗14 d后外周血S100B、NPY表达水平均显著降低(P<0.01),观察组较对照组降低更显著(P<0.01);2组不良反应发生率差异无统计学意义(P>0.05)。结论:银杏达莫联合醒脑静治疗出血性脑病效果显著,协同增效作用明显,且安全性高,值得应用推广。

Objective： To investigate the curative effects of Yinxingdamo and Xingnaojing on patients with cerebral hemorrhage,and effects on peripheral blood S100 B and neuropeptide Y（ NPY）. Methods： A total of 80 cases of patients with cerebral hemorrhage admitted in our hospital from January 2015 to June 2017 were selected and divided into two groups according to the random number table method. The control group was given Xingnaojing treatment,while the observation group was given Yinxingdamo combined with Xingnaojing treatment. The brain edema absorption effect,NIHSS score,peripheral blood S100 B and NPY levels before and after the treatment of the two groups were recorded and compared,and the safety of medication of the two groups was evaluated. Results： After treatment for 14 d,the total effective rate of cerebral hematoma absorption in observation group was 90%,which was significantly higher than that in control group（ 72. 5%）（ P〈0. 01）. NIHSS score in the two groups were all significantly lower than before treatment（ P〈0. 01）,and the improvement effect in observation group was more significant than that in control group（ P〈0. 01）. Compared with that before treatment,the levels of S100 B and NPY in the two groups were all significantly decreased after 14 d treatment（ P〈0. 01）,and the improvement effect in observation group was more significant than that in control group（ P〈0. 01）. There was no significant difference in the incidence of adverse reactions between the two groups（ P〈0. 05）. Conclusion： Yinxingdamo combined with Xingnaojing displays a remarkable synergistic effect in the treatment of hemorrhagic encephalopathy with high safety,so it is worthy of promotion.