二仙汤联合优甲乐对甲状腺功能减退患者血清炎性因子和免疫功能的影响

Effect of Erxian Decoction Combined With Euthyrox on Inflammatory Factor and Immune Function in Patients with Hypothyroidism

目的:探讨二仙汤联合优甲乐对甲状腺功能减退患者血清炎性因子和免疫功能的影响,分析联合治疗可能作用机制。方法:选取2013年6月至2015年6月海淀区中医院收治的甲状腺功能减退症患者148例,据随机数字表法分为对照组与观察组,每组74例,对照组给予优甲乐治疗,观察组联合应用二仙汤治疗,治疗4周后,比较2组患者血清炎性因子、免疫功能、临床疗效等指标。结果:观察组治疗有效率97.30%明显高于对照组的87.84%(χ~2=4.812,P<0.05);血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、高敏C反应蛋白(hs-CRP)水平均明显低于对照组(t=3.946~4.839,P<0.05);治疗4周后观察组CD3^+、CD4^+T细胞比例及CD4/CD8^+比值较对照组升高,而CD8^+、CD16^+T细胞比例较对照组降低(P<0.05)。结论:二仙汤联合优甲乐有助于提高甲状腺激素减退患者临床疗效,可能与降低血清炎性因子水平、改善免疫功能等因素有关。

Objective： To investigate the effect of Erxian decoction combined with euthyrox on inflammatory factor and immune function in patients with hypothyroidism,and to analyze the possible mechanism of action of combined treatment. Methods： A total of 148 patients with hypothyroidism in our hospital were divided into control group and observation group by random number table,with 74 cases in each group. Control group was given euthyrox,while observation group was given Erxian decoction combined with euthyrox. After 4-week treatment,the inflammatory factor,immune function,and clinical efficacy were compared between the two groups. Results： The effective rate of observation group was 97. 30%,which was higher than 87. 84% of control group（ χ~2= 4.812,P〈0. 05）; The tumor necrotic factor-α（ TNF-α）,interleukin-6（ IL-6）,high-sensitivity C-reactive protein（ hs-CRP） content in observation group were lower than that in control group（ t = 3. 946 ~ 4. 839,P〈0. 05）; After 4-week treatment,the ratio of CD3~＋,CD4~＋T cell in observation group increased compared with control group,while the ratio of CD8~＋,CD16~＋T cell decreased compared with control group（ t = 6. 322 ~ 11. 029,P〈0. 05,P〈0. 01）. Conclusion： Erxian decoction combined with euthyrox for patients with hypothyroidism can increase clinical efficacy,decrease the levels of inflammatory factor and improve immune function.