自拟祛痹汤合四妙散对湿热痹阻型类风湿性关节炎患者免疫指标的影响

Influence of Self-made Qubi Decoction Combined with Simiao Powder on Immune Indexes in Patients with Rheumatoid Arthritis with Dampness Heat Retention Type

目的:了解湿热型类风湿性关节炎患者给予自拟祛痹汤合四妙散治疗对免疫指标的影响。方法:选取2013年5月到2016年5月北京市怀柔区中医医院收治的湿热型类风湿性关节炎患者70例,随机分为2组,常规组35例给予西医治疗,观察组35例给予自拟祛痹汤合四妙散治疗,比较2组治疗后血清免疫指标、关节症状恢复及疗效情况。结果:治疗后,观察组IgG、IgA、IgM、RF、ESR等指标均显著低于常规组,差异有统计学意义(P<0.05);观察组C3、C4等指标均显著高于常规组,差异有统计学意义(P<0.05);观察组关节疼痛数、关节压痛数、关节肿胀数等均明显低于常规组,差异有统计学意义(P<0.05);观察组治疗疗效总有效率为94.29%显著高于常规组总有效率82.86%,差异有统计学意义(P<0.05)。结论:自拟祛痹汤合四妙散用于湿热型类风湿性关节炎患者可有效改善患者各项血清免疫指标,且疗效显著,无不良反应。

Objective： To investigate the influence of self-made Qubi Decoction and Simiao powder on immune indexes in patients with dampness heat type rheumatoid arthritis. Methods： A total of 70 cases with the damp heat syndrome of rheumatoid arthritis in our hospital from May 2013 to May 2016 were selected and randomly divided into 2 groups,of which the control group of 35 cases were treated with western medicine treatment and the study groups of 35 cases were treated with Qubi Decoction and Simiao powder. After the treatment,the two groups were compared in terms of serum immune index,joint symptoms and recovery effect. Results： After the treatment,IgG,IgA,IgM,RF and ESR of the study group were significantly lower than the normal group,and the difference was statistically significant（ P〈0. 05）; C3 and C4 of the study group were significantly higher than the normal group,and the difference was statistically significant（ P〈0. 05）; joint pain,joint tenderness,joint the swelling numbers of the study group were significantly lower than the conventional group,and the difference was statistically significant（ P〈0. 05）; the total effective rate of the treatment group was 94. 29%,significantly higher than 82. 86% of conventional group,and the difference was statistically significant（ P〈0. 05）. Conclusion： The self-made Qubi decoction combined with Simiao powder can effectively improve the serum immune indexes of patients with damp heat type rheumatoid arthritis,and the curative effect is remarkable,without side effects.