和血明目片辅助治疗糖尿病眼底出血患者的疗效及对血液流变学的影响

Observation on Curative Effect of Hexue Mingmu Tablets on Diabetic Patients with Fundus Hemorrhage and Effects on Hemorheology

目的:探讨和血明目片辅助治疗糖尿病眼底出血患者的疗效及对血液流变学的影响。方法:选取2014年12月至2016年12月期间榆林市第一医院收治的糖尿病性眼底出血患者98例,按照随机表法分为观察组与对照组,各49例。对照组采用常规西医治疗,观察组在对照组基础上结合和血明目片治疗。2组疗程均为4周。比较2组眼底检查疗效、视力疗效,治疗前后血液流变学水平变化。结果:观察组眼底检查治疗有效率(87.76%)高于对照组(69.39%)(P<0.05);观察组视力治疗有效率(83.67%)高于对照组(65.51%)(P<0.05);2组治疗后全血黏度高切、全血黏度低切、血浆黏度水平降低(观察组t=16.955、11.523、21.609,对照组t=5.920、5.590、9.884,P<0.05);观察组治疗后全血黏度高切、全血黏度低切、血浆黏度水平低于对照组(t=10.812、6.066、14.668,P<0.05);2组患者治疗后血清同型半胱氨酸(Hcy)、三酰甘油(TG)、总胆固醇(TC)水平降低(观察组t=15.760、12.974、19.341,对照组t=7.321、7.331、7.469,P<0.05);观察组患者治疗后血清Hcy、TC和TG水平低于对照组(t=10.826、7.104、12.035,P<0.05)。结论:和血明目片辅助治疗糖尿病眼底出血疗效显著,且可改善血液流变学。

Objective： To investigate the effects of Hexue Mingmu Tablet in the treatment of diabetic patients with fundus hemorrhage,and effects on hemorheology. Methods： A total of 98 patients with diabetic fundus hemorrhage in Yulin firse hospital from December 2014 to December 2016 were randomly divided into observation group（ n = 49） and control group（ n = 49）. The control group was treated with conventional western medicine,while the observation group was treated with the combination of Mingmu tablets and the control group. The two groups were treated for 4 weeks. The curative effect and visual acuity of the two groups were compared,and the changes of hemorheology before and after treatment were compared. Results： The total efficiency of the treatment of fundus examination in the observation group（ 87. 76%） was higher than control group（ 69. 39%）（ P〈0. 05）; The total effective rate of visual treatment in the observation group（ 83. 67%） was higher than that of the control group（ 65. 51%）（ P〈0. 05）;After treatment,high shear whole blood viscosity,low shear blood and plasma viscosity levels decreased in two groups（ observation group t = 16. 955,11. 523,21. 609,control group t = 5. 920,5. 590,9. 884,P〈0. 05）; after treatment,high shear whole blood viscosity,low shear blood and plasma viscosity of observation group was lower than control group（ t = 10. 812,6. 066,14. 668,P〈0. 05）; Serum Hcy,TC and TG decreased after treatment in two groups（ observation group t = 15. 760,12. 974,19. 341,in control group t = 7. 321,7. 331,7. 469,P〈0. 05）; the levels of Hcy,TC and TG levels were lower than the control group after treatment（ t = 10. 826,7. 104,12. 035,P〈0. 05）. Conclusion： Hexue Mingmu Tablet is effective to improve the blood rheology of patients with diabetic fundus hemorrhage.