内热针联合云克疗法治疗膝关节骨性关节炎的疗效及其对患者IL-1和TNF-a水平的影响

Effects of Heat Acupuncture Combined with Yunke Therapy in the Treatment of Osteoarthritis in the Knee Osteoarthritis and Influence on IL-1 and TNF-a level

目的:观察内热针联合云克疗法治疗膝关节骨性关节炎的临床疗效,以及检查其对患者白细胞介素-1(IL-1)和肿瘤坏死因子-a(TNF-a)水平的影响。方法:选取2012年6月至2013年3月武汉市普仁医院收治的膝关节骨性关节炎患者70例,随机分为观察组和对照组,每组35例,观察组患者给予内热针联合云克疗法治疗,对照组患者仅给予云克疗法治疗,疗程为6周。分别测定治疗前和治疗后不同时期2组患者的IL-1和TNF-a水平。并观察2组治疗前和治疗后不同时期膝关节HSS评分。结果:治疗后,2组患者各个时期的IL-1和TNF-a水平较治疗前明显下降(P<0.05);且观察组的IL-1和TNF-a水平较对照组的显著下降,差异有统计学意义(P<0.05);治疗后观察组各个时期的膝关节HSS评分明显高于对照组(P<0.05)。结论:内热针联合云克疗法对治疗膝关节骨性关节炎有着明显的疗效,其机制可能是通过有效地降低抑制膝关节骨性关节炎患者的IL-1和TNF-a水平来减轻炎性反应,从而减缓膝关节的退化,值得临床作进一步推广。

Objective： To observe the clinical effects of heat acupuncture combined with Yunke therapy in the treatment of knee osteoarthritis,and to examine its effects on interleukin-1（ IL-1） levels and tumor necrosis factor-a（ TNF-a） levels in patients with osteoarthritis. Methods： A total of 70 cases of knee osteoarthritis patients who were treated in our hospital from June 2012 to March2013,were randomly divided into experimental group of 35 cases and control group of 35 cases. 35 cases in experimental group were treated with heat acupuncture combined with Yunke therapy,while35 patients in the control group only received Yunke therapy and the treatment lasted for 6 weeks. Patients of two groups were measured in IL-1 and TNF-a levels before and after treatment.And the HSS scores of two groups before and after treatment were observed. Results： After treatment,IL-1 and TNF-a levels of the two groups in each stage were significantly lower than those before treatment（ P〈0. 05）; and IL-1 and TNF-a levels of the experimental group were significantly lower than that of control group. The difference was statistically significant（ P〈0. 05）; HSS score of the experimental group was significantly higher than that of the control group（ P〈0. 05）. Conclusion： Heat acupuncture combined with Yunke therapy in the treatment of knee osteoarthritis has significant effects,the mechanism of which may be through effectively reducing IL-1 and TNF-a levels in patients with knee osteoarthritis to alleviate the inflammatory response,thereby slowing the degradation of the knee. It is worthy of further promotion.