转录因子在滋养细胞浸润行为调控中的作用

Role of transcription factors in regulation of trophoblast invasion

在妊娠早期,滋养细胞的浸润调控对维持母胎界面的胎盘功能发挥着重要作用,该文综述转录因子如过氧化物酶体增殖物激活受体、转录因子激活蛋白-2α、碱性螺旋-环-螺旋蛋白家族、GCM1、核转录因子及同源异型盒基因家族等在滋养细胞浸润的调节过程中的作用机制,有利于进一步阐明滋养细胞浸润相关性疾病的发病机制。

Regulation of trophoblast invasion plays an important role in maintaining placental function in early pregnancy stage. This article reviewed role of transcription factors including peroxisome proliferator-activated receptor, transcription factor activator protein-2α, basic helix-loop-helix protein family, glial cell missing 1 （GCM1）, nuclear transcription factor and homeobox gene family in regulating trophoblast invasion. This further elucidates the potential pathogenesis of trophoblast invasion related diseases.