广泛性脑萎缩者血浆tau蛋白、磷酸化tau蛋白水平与认知功能的关系

Relationship between plasma tau protein,p-tau protein and cognitive function in elderly patients with global brain atrophy

目的探讨血浆tau蛋白、磷酸化tau蛋白(p-tau)蛋白与广泛性脑萎缩者认知功能的关系。方法纳入100名中、重度广泛性脑萎缩者,记录性别、年龄、受教育程度等一般情况,按认知功能不同分为两组:正常组(n=50例)和痴呆组(n=50例)。应用双抗体夹心酶联免疫吸附法测定血浆tau蛋白、p-tau蛋白含量,分析两组患者血浆tau蛋白、p-tau蛋白的表达差异及其与认知功能的关系。结果痴呆组血浆tau蛋白、p-tau蛋白水平[(210.92±43.79)pg/m L、(81.15±16.85)pg/m L]较正常组[(210.92±43.79)pg/m L、(81.15±16.85)pg/m L]明显升高(P<0.05),tau蛋白、p-tau蛋白水平均与MMSE评分值呈负相关(均P<0.05),与脑萎缩程度无明显相关性(P>0.05)。结论广泛性脑萎缩患者出现认知损害可能与tau蛋白水平升高有关。

Objective To investigate the relationship between plasma tau protein, phosphorylated tau protein （ptau） protein and cognitive function in subjects with generalized brain atrophy. Methods A total of 100 subjects with moderate and severe brain atrophy were divided into two groups according to cognitive function： normal group （n=50 cases） and dementia group （n=50 cases）. And their gender, age, educational level, etc. are recorded. The tau protein and p-tau protein content in plasma were measured by double antibody sandwich enzyme-linked immunosorbent assay （ELISA）. The differences between plasm tau and p-tau protein expression and their relationship with cognitive function were analyzed. Results Plasma tau protein and p-tau protein levels were significantly higher （P〈0.05） in the dementia group [（210.92±43.79）pg/mL, （81.15±16.85）pg/mL] than in the normal group[（210.92±43.79）pg/mL, （81.15±16.85）pg/ mL]. Plasma tau protein and p-tau protein levels were negatively correlated with the MMSE score （P〈0.05） and had no significant correlation with the degree of brain atrophy （P〉0.05）. Conclusion Cognitive impairment may be associated with elevated tau protein levels in patients with extensive brain atrophy.