心脉隆注射液联合左旋卡尼汀对慢性充血性心力衰竭的疗效及血清BNP、CRP的影响研究

Effect of Xinmaonong Injection Combined with LCarnitine on Chronic Congestive Heart Failure and Serum BNP and CRP

目的探讨心脉隆注射液联合左旋卡泥汀对慢性充血性心力衰竭的疗效及BNP、CRP的影响研究。方法选取120例慢性充血性心力衰竭患者,随机分为观察组与对照组,对照组采用常规药物治疗,观察组在常规药物治疗基础上加用心脉隆注射液联合左旋卡泥汀治疗,对比分析两组患者疗效、治疗前后心功能指标、血清BNP、CRP指标。结果观察组治疗有效率为91.7%,对照组治疗有效率为75.0%,观察组治疗有效率明显高于对照组(P<0.05),两组患者治疗前BNP、CRP比较差异无统计学意义,治疗后观察组与对照组BNP、CRP较治疗前均有明显好转,差异具有统计学意义(P<0.05),治疗后观察组BNP、CRP指标改善明显优于对照组(P<0.05),两组患者治疗前LEVF、CO、6 min步行试验、NYHA心功能分级比较差异无统计学意义,治疗后两组患者LEVF、CO、6 min步行试验、NYHA心功能分级均明显优于治疗前,差异具有统计学意义(P<0.05),治疗后观察组LEVF、CO、6 min步行试验、NYHA心功能分级三个指标明显优于对照组(P<0.05)。结论采用心脉注射液联合左旋卡泥汀治疗慢性心力衰竭能明显提高疗效,改善患者心功能指标,值得在临床中推广应用。

Objective To investigate the effect of Xinmailong injection combined with card and BNP,CRP Ting mud curative effect on chronic congestive heart failure.Methods Selected 120 cases of chronic congestive heart failure,randomly divided into observation group and control group,the control group with routine drug treatment,observation group based on routine therapy on Xinmailong injection combined with mud treatment card Ting comparative analysis before and after treatment,the curative effect,two groups of patients with cardiac function index,serum BNP,CRP index.Results The effective rate of treatment group was 91.7%,the effective rate of the control group was 75%,the treatment efficiency of observation group was significantly higher than the control group(P<0.05),before BNP,two groups of patients have no obvious difference in CRP,the difference was not statistically significant after treatment,the observation group and the control group BNP,CRP compared with before treatment were significantly improved(P<0.05),the difference was statistically significant(P<0.05),the observation group after treatment BNP,CRP index improved significantly better than the control group(P<0.05),two groups of patients before treatment,LEVF,CO,6 min walk test,NYHA grade of heart function had no significant difference.No significant difference was found between two groups after the treatment,LEVF,CO,6 min walking test and NYHA cardiac functional grading were significantly better than before treatment(P<0.05),the difference was statistically significant(P<0.05),the observation group after LE treatment The three indexes of VF,CO,6 min walk test and NYHA cardiac function classification were significantly better than those of control group(P<0.05).Conclusion The treatment of chronic heart failure with heart vein injection combined with levamisole can obviously improve the curative effect and improve the cardiac function index,which is worthy of clinical application.