摘要
对家兔用胶原酶施行实验性髓核化学溶解术。结果表明,胶原酶注射后3周,腰椎间盘髓核(LNP)总胶原和可溶性胶原可增多,这似与组织损伤后胶原纤维的反应性增生有关;胶原酶虽然并不影响蛋白多糖的总量,但可使糖醛酸与氨基多糖的比值变小,提示它能够改变各类氨基多糖的比例,引起组织的纤维软骨化。
The experimental chemonucleolysis was performed in rabbits withcollagenase.The results showed that 3 weeks after injection of collagenase,thecontents of total and soluble collagen increased because of reactive fibrosis relatedwith traumatized tissue;the ratio of uronic acids to glycosaminoglycans decreased,although the content of proteoglycans dip not change.Those changes suggestedthat chemonucleolysis with collagenase may cause the dissolution of collagen andreactive fibrosis of LNP.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第1期17-20,共4页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金
国家教委博士点基金
关键词
胶原酶
胶原
蛋白多糖
髓核
collagen
proteoglycan
chemonucleolysis
collagenase
lumbar nucleus pulposus(LNP)
