VITB_(12)与叶酸对急性脑梗死患者的血管内皮功能及Hcy水平的影响

Effects of VITB_(12) and folic acid on vascular endothelial function and Hcy level of patients with acute cerebral infarction

目的浅探VITB_(12)与叶酸对急性脑梗死患者的血管内皮功能及Hcy水平的影响。方法选取本院2015年1月~2017年3月期间收治的116例急性脑梗死患者,按照随机数字法分为干预组和对照组,各58例。对照组患者给予包括抗凝、抗血小板、调脂控压及营养神经等常规治疗方法。干预组患者在对照组治疗方法的基础上给予患者VITB_(12)及叶酸治疗,观察两组患者的临床疗效及血管内皮功能与Hcy水平变化。结果两组患者治疗后NIHSS及BI评分均有明显改善(P<0.05)。干预组治疗后NIHSS及BI评分明显优于对照组(P<0.05)。两组患者治疗后FMD及Hcy水平评分均显著优于治疗前(P<0.05)。干预组治疗后FMD及Hcy水平明显优于对照组(P<0.05)。干预组有效率为82.76%,对照组有效率为62.07%,两组数据比较差异有统计学意义(P<0.05)。结论 VITB_(12)与叶酸能够有效改善急性脑梗死患者血管内皮功能及Hcy水平,临床疗效满意。VITB_(12)与叶酸可作为急性脑梗死患者临床重要辅助治疗用药进行推广。

Objective To explore the effect of VITB_(12) and folic acid on vascular endothelial function and Hcy level of patients with acute cerebral infarction. Methods 116 patients with acute cerebral infarction in our hospital from January 2015 to March 2017 were randomly divided into intervention group and control group by random number method, 58 cases in each groups. Patients in control group were treated by conventional treatment, including usage of anticoagulant and anti-platelet, control of blood fat and blood pressure, neurotrophic activity and other. Patients in intervention group were treated by VITB_(12) and folic acid on the basis of the control group. The clinical efficacy, vascular endothelial function and Hcy level in the two groups were observed. Results NIHSS and BI scores were significantly improved in both groups(P<0.05). After treatment, NIHSS and BI scores of the intervention group were significantly better than those of the control group(P<0.05). The scores of FMD and Hcy in the two groups were significantly better after treatment(P<0.05). After treatment, FMD and Hcy in the intervention group were significantly better than those in the control group(P<0.05). The effective rate of intervention group was 82.75%, and effective rate of control group was 62.07%, there was significant difference between the two groups. Conclusion VITB_(12) and folic acid can effectively improve the vascular endothelial function and Hcy level of patients with acute cerebral infarction, and the clinical curative effect is satisfactory. VITB_(12) and folic acid can be used as an important adjuvant therapy for patients with acute cerebral infarction.