单唾液酸四己糖神经节苷脂联合1,6-二磷酸果糖对新生儿窒息并发缺血缺氧性脑病患儿心功能、肾功能和血糖的影响

Effect of monosialoteterahexosylganglioside combined with fructose-1,6-diphosphate on cardiac function,renal function and blood glucose in newborn infants with asphyxia complicated by hypoxic ischemia encephalopathy

目的:探讨单唾液酸四己糖神经节苷脂(GM1)联合1,6-二磷酸果糖(FDP)对新生儿窒息(NA)并发缺血缺氧性脑病(HIE)患儿心功能、肾功能和血糖的影响。方法:选取2015年12月至2016年12月广东省汕头市潮阳区大峰医院收治的NA并发HIE患儿120例,随机分为A组和B组,每组60例。A组给予GM1治疗,B组在此基础上给予FDP治疗。比较两组患儿血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、尿素氮(BUN)、血肌酐(SCR)及血糖水平。记录两组新生儿神经行为评分(NBNA)。结果:治疗后,B组血清CK、CK-MB、BUN、SCR及血糖水平均明显低于A组和治疗前,NBNA评分明显高于A组和治疗前,差异均有统计学意义(均P<0.05)。结论:GM1联合FDP治疗可有效改善NA并发HIE患儿的心功能、肾功能、血糖水平以及神经行为。

Objective： To investigate the effect of monosialotetrahexosylganglioside（GM1）combined with fructose-1,6-diphosphate（FDP）on cardiac function,renal function and blood glucose in newborn infants with asphyxia complicated by hypoxic ischemia encephalopathy（HIE）. Methods： From December 2015 to December 2016,120 cases with neonatal asphyxia（NA）complicated with HIE in our hospital were selected and randomly divided into group A and group B,with 60 cases in each group. The infants in group A were treated with GM1,and those in group B were treated with GM1 and FDP. The creatine kinase（CK）,creatine kinase isoenzyme（CK-MB）,urea nitrogen（BUN）,and serum creatinine（SCR）levels as well as neonatal behavioral neurological assessment（NBNA）score were detected and compared. Results： After treatment,the serum levels of CK,CK-MB,BUN,SCR and blood glucose in group B were significantly lower than those in group A,while the NBNA score was notably higher（P〉0. 05）. Conclusion： The combination of GM1 and FDP could effectively improve the cardiac function,renal function,neurological function and blood glucose level in newborn infants with asphyxia complicated by HIE.