PNPLA3基因多态性与非酒精性脂肪性肝病肝损伤间相关性的系统评价

Association between the polymorphism of the PNPLA3 rs738409 gene and liver damage and the steatosis of liver:a Meta-analysis

目的系统评价PNPLA3rs738409基因突变与非酒精性脂肪性肝病肝损伤的相关性。方法计算机检索Pub Med、CNKI、Embase、Ovid数据库,搜索有关PNPLA3rs738409基因多态性与单纯非酒精性肝病肝损伤相关性的横断面研究,检索时限为建库至2017年4月,由2位研究人员独立筛选,提取数据资料后用STATA12.0软件进行Meta分析。结果在PNPLA3rs738409位点发生突变的患者体内,丙氨酸氨基转移酶、天门冬氨酸氨基转移酶水平明显高于未发生突变的人群,而在三酰甘油、胆固醇水平的研究中二者差异无统计学意义(P>0.05)。结论 PNPLA3基因的突变与非酒精性脂肪性肝病肝损伤有密切相关性。

Objective To systematically review the association between PNPLA3 polymorphism and liver damage and the steatosis of liver. Methods Databases including Pub Med, CNKI, Embase and Ovid were searched via electronically from inception to April 2017, cross-sectional studies about the association between the polymorphism of the PNPLA3 rs738409 gene and liver damage and the steatosis of liver were collected. Two reviewers independently screened literature, extracted data and assessed the methodological quality in- cluded studies. Then,Meta-analysis was performed using STATA 12.0 software. Results The results of Me- ta-analysis showed that the level of alanine aminotransferase and aspartate aminotransferase of the patients with PNPLA3 rs738409 gene mutated were distinctly higher than those of normal patients,while the research of triglyceride and total cholesterol showed no difference between the two groups（P〉0.05）. Conclusion PNPLA3 polymorphism is closely associated with liver damage and the steatosis of liver.