坦度螺酮联合氟哌啶醇治疗对酒精所致精神障碍患者BDNF和NGF水平的影响

Effect of combination of tandospirone and haloperidol on the levels of BDNF and NGF in patients with mental disorders due to alcohol

目的探讨坦度螺酮联合氟哌啶醇对酒精所致精神障碍患者血清脑源性神经营养因子(BDNF)和血清神经生长因子(NGF)水平的影响。方法选取云南省传染病专科医院收治的80例酒精所致精神障碍患者,分为氟哌啶醇组(氟哌啶醇治疗)和联合治疗组(坦度螺酮联合氟哌啶醇治疗),每组40例。采用酶联免疫吸附试验检测两组患者治疗前后BDNF和NGF水平,并比较两组患者治疗前后阳性与阴性症状量表(PANSS)评分。结果治疗后两组患者BDNF和NGF水平均明显上升,而PANSS评分明显下降,差异均有统计学意义(P<0.05),且联合治疗组患者变化幅度均大于氟哌啶醇组,差异有统计学意义(P<0.05)。结论坦度螺酮联合氟哌啶醇可明显降低酒精所致精神障碍患者BDNF和NGF水平,且有效降低酒精所致精神障碍患者的PANSS评分。

Objective To investigate the effects of halftamol combined with haloperidol on serum brain-de-rived neurotrophic factor （BDNF） and serum nerve growth factor （NGF） in patients with mental disorders caused by alcoholism. Methods 80 patients with mental disorders caused by alcoholism were selected from Yunnan Infectious Disease Specialist Hospital, they were randomly divided into haloperidol group （treated with haloperidol） and combined treatment group （treated with buspirone combined with haloperidol） ,40 cases in each group. The therapeutic effect was evaluated after 6 weeks of drug treatment, and the changes of BDNF and NGF in serum were measured by enzyme linked immunosorbent assay（ELISA） method before and after treatment. The positive and negative symptom scores before and after treatment were observed and compared. Results Serum BDNF and NGF concentrations were significantly increased after haloperidol treatment and combination therapy. The levels of serum BDNF and NGF increased more significantly after treatment with tandospirone and haloperidol （P〈0.05）. Patients in the haloperidol treatment and combination therapy signif- icantly reduced PANSS score;Compared with the haloperidol group,PANSS scores were significantly lower in patients treated with tandospirone and haloperidol （P〈0.05）. Conclusion Tandospirone combined with halo- peridol has significant effects on serum BDNF and NGF levels in mental disorders caused by alcoholism. And halftamol combined with haloperidol effectively reduced the PANSS score in patients with mental disorders caused by alcohol.