吲哚布芬中间体2-(4-氨基苯基)丁酸的合成

Synthesis of Indobufen Intermediate 2-(4-aminophenyl) Butyric Acid

吲哚布芬是新一代抗血小板聚集药,本文以α-苯基丁腈为起始原料,通过硝化反应生成2-(4-硝基苯基)丁腈,再经水解反应生成2-(4-硝基苯基)丁酸,最后用保险粉还原硝基最终合成了吲哚布芬关键中间体2-(4-氨基苯基)丁酸,并对其合成过程进行了优化,减少了步骤和废液的产生,提高了收率和产品质量。

Indobufen is a new generation of antiplatelet drugs, In this paper, alpha-phenylbutyronitrile was used as the starting material, and 2-（4-nitrophenyl）butyronitrile was obtained by nitrification reaction, and 2-（4-nitrophenyl）butyric acid was produced by hydrolysis reaction, and the final synthesis of the key intermediate of indobufen 2-（4-aminophenyl）butyric acid was synthesized by using the insurance powder to reduce the nitro group. The synthesis process was optimized, and the production of the process and waste liquid was reduced, and the yield and quality of product were improved.