自噬对间充质干细胞的生物学作用研究进展

Research progress of autophagy in mesenchymal stem cells

自噬是细胞器或蛋白质受损、变性、衰老时,通过溶酶体途径运输到溶酶体区进行降解、循环与再利用的生物学过程。作为主要的细胞内降解和循环途径,自噬在正常细胞和组织发育过程中对于维持和重塑细胞稳态至关重要。间充质干细胞(MSCs)是一种具有自我更新能力的多能祖细胞,并可以分化成新的组织,因而在再生医学中具有一定的应用潜能,且在多种退行性疾病的生物学治疗中显示出重要效果。自噬可以影响MSCs的干性维持及干细胞的分化。本文就自噬对MSCs的生物学作用研究进展进行综述。

Autophagy is a life-sustaining process used by the cell to deliver cytoplasmic components to the lysosome for degradation and recycle. As a major intracellular degradation and circulation pathway, autophagy is essential for maintaining and remodeling cell homeostasis during normal development of cell and tissue. Mesenchymal stem cells （MSCs） are pluripotent progenitor cells with self-renewal capabilities which play an important role in the treatment of degenerative disease. Recent studies have demonstrated that autophagy is necessary for the maintenance of cellular sternness and for a number of differentiation processes, including the lineage determination of MSCs. Here, we review the current literature by various extra- or intracellular stimuli and the differentiation. on the complex relation between autophagy induced molecular targets that affect MSCs proliferation and differentiation.